期刊
ORGANIC LETTERS
卷 16, 期 6, 页码 1764-1767出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol500464x
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资金
- Pennsylvania State University
- NSF [CAREER CHE-1055795]
- ACS-PRF [51705-DN11]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1055795] Funding Source: National Science Foundation
In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.
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