期刊
ORGANIC LETTERS
卷 16, 期 23, 页码 6044-6047出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5026603
关键词
-
资金
- NIH [P41 GM068944]
- [PJ009643]
The new tuberculosis (TB) lead ecumicin (1), a cyclic tridecapeptide, was isolated from Nonomuraea sp. MJM5123, following a high-throughput campaign for anti-TB activity. The large molecular weight of 1599 amu detected by LC-HR-MS precluded the initial inference of its molecular formula. The individual building blocks were identified by extensive NMR experiments. The resulting two possible planar structures were distinguished by LC-MS2. Determination of absolute configuration and unambiguous structural confirmation were carried out by X-ray crystallography and Marfey's analysis.
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