Sc(OTf)3-Catalyzed Transfer Diazenylation of 1,3-Dicarbonyls with Triazenes via N-N Bond Cleavage

A new and efficient method for diazenylation reactions was developed with a Sc(OTf)(3)-catalyzed nitrogen-nitrogen bond cleavage process with triazenes. The transfer diazenylation reactions accommodate a diverse range of active methylene substrates including simple ketones to give aliphatic azo compounds that are of significant potential as azo prodrugs in high yields under mild conditions.