4.8 Article

α-Ketophosphonates as Ester Surrogates: Isothiourea-Catalyzed Asymmetric Diester and Lactone Synthesis

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ORGANIC LETTERS
卷 16, 期 9, 页码 2506-2509

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AMER CHEMICAL SOC
DOI: 10.1021/ol500873s

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  1. Royal Society
  2. EPSRC
  3. GSK
  4. Pfizer
  5. EU
  6. European Research Council under the European Union [279850]
  7. European Research Council (ERC) [279850] Funding Source: European Research Council (ERC)

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Isothiourea HBTM-2.1 catalyzes the asymmetric Michael addition/lactonization of aryl- and alkenylacetic acids using alpha-keto-beta,gamma-unsaturated phosphonates as alpha,beta-unsaturated ester surrogates, giving access to a diverse range of stereodefined lactones or enantioenriched functionalized diesters upon ring-opening.

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