期刊
ORGANIC LETTERS
卷 16, 期 3, 页码 864-867出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol403631k
关键词
-
资金
- Welch Foundation [AX-1788]
- Max and Minnie Tomerlin Voelcker Fund
- University of Texas at San Antonio
- National Institute on Minority Health and Health Disparities [G12MD007591]
A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of copper catalysis and activation by lithium fluoride or magnesium chloride. The utility of this method for the late-stage modification of complex N-heterocycles is exemplified by facile syntheses of new structural analogues of several antimalarial, antimicrobial, and fungicidal agents.
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