Synthesis of Phosphoramidates: A Facile Approach Based on the C-N Bond Formation via Ir-Catalyzed Direct C-H Amidation

A new synthetic route to phosphoramidates by intermolecular C-H amidation is presented. Substrates with assorted directing groups were activated by an iridium-based catalyst system and reacted with a number of phosphoryl azides, executing efficient phosphoramidate synthesis via C-N bond formations.