4.8 Article

Ruthenium(II)-Catalyzed C(sp3)-H α-Alkylation of Pyrrolidines

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ORGANIC LETTERS
卷 16, 期 7, 页码 1876-1879

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AMER CHEMICAL SOC
DOI: 10.1021/ol500300w

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  1. European Research Council under the European Community/ERC [307535]
  2. Chinese Scholarship Council

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A catalytic system comprising [RuCl2(PPh3)(3)], AgOTf, and BINAP enabled atom- and step-economical additions of C(sp(3))-H bonds onto unactivated alkenes 2 under comparably mild reaction conditions. The pyridyl directing group was easily removed to furnish the corresponding (NH)-free amines with ample scope.

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