Oxime-Mediated Facile Access to 5-Methylisoxazoles and Applications in the Synthesis of Valdecoxib and Oxacillin

A palladium-Catalyzed efficient synthesis of 5 methylisoxazoless Via oxime-mediated functionalization of unactivated olefins is described. The reaction affords'aVariety: of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the imethod, the rapid synthesis of valdecoxib and oxacillin is reported.