Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement

A novel domino copper-catalyzed trifluoromethylated Meyer-Schuster rearrangement reaction with Togni's reagent was developed, leading to a-trifluormethyl (CF3) enone products with moderate to good yields. Furthermore, alpha-CF3 enones can be transformed toward important trifluoromethyl heterocyclic motifs in a one-pot version.