Three-Component Coupling Reaction Triggered by Insertion of Arynes into the S=O Bond of DMSO

An unprecedented three-component coupling reaction of arynes, alpha-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the S=O bond of DMSO has been developed. The reaction can generate a wide range of multisubstituted aryl methyl thioethers in good yields, wherein DMSO serves as both methylthiolation reagent and oxygen source.