期刊
ORGANIC LETTERS
卷 16, 期 15, 页码 4004-4007出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol501829k
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资金
- NNSFC [21172030, 21272034, 21202015]
alpha-Acidic isocyanides are versatile reagents in organic synthesis, especially for the synthesis of five-membered heterocycles via [3 + 2]-cycloaddition reactions with activated multiple bonds. In this communication, the first [3 + 3]-cross-cycloaddition of alpha-acidic isocyanides with 1,3-dipolar azomethine imines to generate a series of 1,2,4-triazine derivatives with significant regiochemical control under mild catalytic reaction conditions is described. This new strategy shows that alpha-acidic isocyanides can also be taken as potent reagents for the synthesis of six-membered heterocycles through [3 + 3]-cross-cycIoaddition reactions with 1,3-dipoles.
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