期刊
ORGANIC LETTERS
卷 16, 期 8, 页码 2224-2227出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5007345
关键词
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资金
- NSFC [30873200, 41176125, 81202453]
- Marine 863 Project [2013AA092902]
- International S&T Cooperation Program of China [0S2014GR0014]
- Hundred Talents Program of SMCH [XBR2013111]
- NSFHEIJP [11KJB350003]
Swinhoeisterols A (1) and B (2), two novel sterols with an unprecedented 6/6/5/7 ring system, were isolated from the sponge Theonella swinhoei. The structures and absolute configurations were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, modified Mosher's method, and TDDFT/ECD calculations. The cytotoxicity of these compounds toward A549 and MG-63 cells encourages studies on their potential target using an inverse virtual screening approach. The predicted inhibitor of h(p300) was corroborated by an in vitro biological test.
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