期刊
ORGANIC LETTERS
卷 16, 期 18, 页码 4904-4907出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5024163
关键词
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资金
- Amgen predoctoral fellowship
- Tri-Institutional PhD Program in Chemical Biology (MSKCC, Weill-Cornell Medical College, Rockefeller University)
The first total synthesis of aspeverin, a prenylated indole alkaloid isolated from Aspergillus versicolor in 2013, is described. Key steps utilized to assemble the core structure of the target include a highly diastereoselective Diels-Alder reaction, a Curtius rearrangement, and a unique strategy for installation of the geminal dimethyl group. A novel iodine(III)-initiated cyclization was then used to install the bicyclic urethane linkage distinctive to the natural product.
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