期刊
ORGANIC LETTERS
卷 16, 期 7, 页码 2014-2017出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol500583d
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资金
- National Science Foundation of China [21102038]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1061]
- Program for Innovative Research Team in University of Henan Province [2012IRTSTHN006]
A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.
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