The First One-Pot Synthesis of L-7-Iodotryptophan from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans

A simple and scalable one-pot biotransformation enables direct access to L-halotryptophans, including L-7-iodotryptophan, from the corresponding haloindoles. The biotransformation utilizes an easy to prepare bacterial cell lysate that may be stored as the lyophilizate for several months and utilized as a catalyst as and when required.