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Lewis Basicity Modulation of N-Heterocycles: A Key for Successful Cross-Metathesis

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ORGANIC LETTERS
卷 16, 期 19, 页码 4972-4975

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AMER CHEMICAL SOC
DOI: 10.1021/ol502016h

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Cross-metathesis involving N-heteroaromatic olefinic dervatives is disclosed. The introduction of an appropriate substitutent on the heteroaromatic ring decreases the lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.

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