期刊
ORGANIC LETTERS
卷 16, 期 12, 页码 3280-3283出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5012899
关键词
-
资金
- National Natural Science Foundation of China [21272279]
Benzoquinone ansamycin antibiotic herbimycin A was synthesized in 19 linear steps and 4.2% yield. Highlighted is the design of a chiral gamma-lactone as the C11-C15 synthon that enabled a facile catalytic asymmetric synthesis of the challenging C8-C20 fragment of the target molecule. The easy access to the stereogenic centers and high overall yield made the strategy applicable in the molecular editing of benzoquinone ansamycins.
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