期刊
ORGANIC LETTERS
卷 16, 期 19, 页码 5056-5059出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5024097
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资金
- Royal Society of New Zealand
The total synthesis of (-)-aspergilazine A, an alkaloid possessing a rare N1' to C6 bisindole bond, is described. A palladium-catalyzed N-arylation was used to selectively install the N1'-C6 bond in the presence of three other possible arylation sites. The ligand XPhos displayed a unique capability to efficiently carry out the N-arylation while simultaneously suppressing epimerization of the sensitive C9 stereocenters. This total synthesis has confirmed that aspergilazine A is a dimer of brevianamide F.
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