期刊
ORGANIC LETTERS
卷 16, 期 22, 页码 5902-5905出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol502900j
关键词
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资金
- 973 Program [2013CB910700]
- National Natural Science Foundation of China [81373270]
- Shenzhen Science and Technology Innovation Commission [ZDSYZ20130331145112855, KQTD201103]
Highly substituted chiral hydantoins were readily synthesized from simple dipeptides in a single step under mild conditions. This reaction proceeded through the dual activation of an amide and a tert-butyloxycarbonyl (Boc) protecting group by Tf2O-pyridine. This method was successfully applied in the preparation of a variety of biologically active compounds, including drug analogs and natural products.
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