4.8 Article

Boron-Heck Reaction of Cyclic Enaminones: Regioselective Direct Arylation via Oxidative Palladium(II) Catalysis

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卷 16, 期 6, 页码 1574-1577

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AMER CHEMICAL SOC
DOI: 10.1021/ol500105d

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  1. National Institutes of Health [GM081267]
  2. University of Minnesota through the Vince and McKnight Endowed Chairs

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An oxidative boron Heck reaction of cyclic enaminones with arylboronic acids is reported. This protocol provides a regioselective arylation it the C6 position of cyclic enaminones. When an N-carbamylated cyclic enaminone was employed, a switch to a conjugate addition reaction occurred in the presence of acid.

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