Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis

Intermolecular aminotrifluoromethylation of alkenes catalyzed by [Ru(bpy)(3)](2+) under visible light irradiation has been explored. The present photocatalytic protocol achieves highly efficient and regioselective difunctionalization of C=C bonds, leading to a variety of beta-trifluoromethylamines. The reaction is applied to late-stage aminotrifluoromethylation of steroid and amino acid scaffolds.