期刊
ORGANIC LETTERS
卷 15, 期 14, 页码 3498-3501出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400974z
关键词
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资金
- MINECO [CTQ2008-00947/BQU, CTQ2012-38594-C02-01]
- DEC Generalitat de Catalunya [2009SGR623]
- ICIQ Foundation
A polystyrene (PS) supported bifunctional squaramide organocatalyst promotes fast Michael addition of 2-hydroxy-1,4-naphthoquinone to nitroalkenes with very high enantioselectivities at low catalyst loadings. The polystyrene supported catalyst can be recycled up to 10 times without any decrease in enantioselectivity (average 96% ee) and adapted to continuous flow operation (24 h). A single flow experiment involving six different nitroalkenes in a sequential manner highlights the applicability of this methodology for rapid access to chemical diversity.
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