期刊
ORGANIC LETTERS
卷 15, 期 14, 页码 3526-3529出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400933x
关键词
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资金
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National Natural Science Fund of China [81072573, 81172978, 81001394, 41106127, 81173635]
- Shanghai Subject Chief Scientist [12XD1400200]
- National High Technology Research and Development Program of China (863 Projects) [2011AA09070107, 2013AA092902]
- Gaussian 03 computational service of Shanghai Super Computing Center
Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 mu M for each fungus.
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