期刊
ORGANIC LETTERS
卷 15, 期 4, 页码 780-783出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303435y
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资金
- NIH [1R01GM085128, 1DP1GM106413, R01AI073829]
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC50 of 3 mu M, suggestive of a physiological role as an immunosuppressive agent.
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