期刊
ORGANIC LETTERS
卷 15, 期 12, 页码 3118-3121出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401327r
关键词
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资金
- Williams College
- Croucher Foundation
- EPSRC
- Commonwealth Trust
A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the requisite stereochemistry and features a crucial boron-mediated aldol coupling of an N-vinylformamide-bearing methyl ketone with a macrocyclic aldehyde to introduce the full side chain. The synthesis of two novel C21-C34 side chain analogs is also reported.
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