期刊
ORGANIC LETTERS
卷 15, 期 9, 页码 2278-2281出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400856g
关键词
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资金
- Pfizer Global Research Development
- BP endowment
A flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6-75 min). In three examples the system was scaled to deliver 50 mmol of product.
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