4.8 Article

Arylation of Aldehyde Homoenolates with Aryl Bromides

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卷 15, 期 9, 页码 2298-2301

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AMER CHEMICAL SOC
DOI: 10.1021/ol4008876

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  1. NSF [CHE-0848460 (GOALI), 1152488]
  2. Division Of Chemistry
  3. Direct For Mathematical & Physical Scien [1152488] Funding Source: National Science Foundation

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A mild palladium catalyzed coupling of reactive aldehyde homoenolates with aryl bromides is described. Aldehyde homoenolates are generated by ring opening of cyclopropanols via a C-C cleavage step. The coupling generates aldehyde products at room temperature in 59-93% yield.

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