4.8 Article

Free-Amine Directed Arylation of Biaryl-2-amines with Aryl Iodides by Palladium Catalysis

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ORGANIC LETTERS
卷 15, 期 17, 页码 4544-4547

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AMER CHEMICAL SOC
DOI: 10.1021/ol402207g

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  1. Zhejiang Province [2011C11097]
  2. NSFC [2107216, 1272205]
  3. Program for Zhejiang Leading Team of ST Innovation

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A new palladium-catalyzed free-amine directed arylation of C(sp(2)) H bonds in the presence of AgOAc and TFA is described. Biaryl-2-amines react with various aryl iodides to give the corresponding mono- or diarylated products with exclusive regioselectivity.

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