期刊
ORGANIC LETTERS
卷 15, 期 14, 页码 3598-3601出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401449b
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资金
- CAS
- National Natural Science Foundation [21272234]
- National S&T Major Special Project on Major New Drug Innovation [2011ZX09102-010]
- Guangdong Natural Science Foundation [S2011010003705]
For the first time, copper-catalyzed intramolecular N-arylation was successfully applied to the kinetic resolution strategy. Under the catalysis of Cul-BINOL derived ligands, the kinetic resolution of rac-2-amino-3-(2-iodoaryl)propionates and rac-2-amino-4-(2-iodoaryl)butanoates afforded chiral intramolecular coupling products and recovered the starting materials in high enantioselectivity (s factors up to 245).
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