4.8 Article

Palladium-Catalyzed Oxidative Aminocarbonylation: A New Entry to Amides via C-H Activation

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ORGANIC LETTERS
卷 15, 期 13, 页码 3370-3373

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AMER CHEMICAL SOC
DOI: 10.1021/ol401419u

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  1. Chinese Academy of Sciences
  2. National Natural Science Foundation of China [21222203, 21172226, 21133011]

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A novel palladium-catalyzed oxidative aminocarbonylation reaction via C(sp(3))-H activation was established, which provides a convenient and general method for the construction of arylacetamides via the carbonylation reaction of alkyl aromatics and amines. By using this protocol, the marketed drug ibuprofen could be easily obtained.

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