期刊
ORGANIC LETTERS
卷 15, 期 9, 页码 2144-2147出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol4006294
关键词
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资金
- Ministry of Education, Culture, Sports, and Technology (MEXT), Japan
- Japan Society for the Promotion of Science for Young Scientists [249927]
- US NSF
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1265652] Funding Source: National Science Foundation
- Grants-in-Aid for Scientific Research [23655088, 21106003] Funding Source: KAKEN
A hydroxymethylation reaction of a variety of iodoarenes proceeded effectively in the presence of CO, NHC-borane, diMelmd-BH3 (2) as a radical mediator, and a catalytic amount of AIBN. The reaction took place chemoselectively at the aryl-iodine bond but not at the aryl-bromine and aryl-chlorine bonds. A three-component coupling reaction comprising aryl iodides, CO, and electron-deficient alkenes also proceeded well to give unsymmetrical ketones in good yields. Control experiments show that 2 would act as a hydrogen donor to acyl radicals and iodinated NHC-borane as a reducing agent of aldehydes.
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