4.8 Article

Smooth Isoindolinone Formation from Isopropyl Carbamates via Bischler-Napieralski-Type Cyclization

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ORGANIC LETTERS
卷 16, 期 2, 页码 358-361

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AMER CHEMICAL SOC
DOI: 10.1021/ol403142d

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  1. MEXT-Supported Program for the Strategic Research Foundation at Private Universities

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Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.

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