期刊
ORGANIC LETTERS
卷 15, 期 11, 页码 2854-2857出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401181a
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- CNRS
- ANR
- ICSN
A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford alpha-acetamidoamides in good to excellent yields.
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