期刊
ORGANIC LETTERS
卷 15, 期 22, 页码 5622-5625出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol402950a
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资金
- CSIR, New Delhi
This is the first report of an innovative, one-pot, organocatalyzed, multicomponent synthesis of 3H-pyrroles from ketones, thiols, and malononitrile in ecofriendly solvent water. The approach to 3H-pyrroles presented herein offers, for the first time, an unprecedented coupling which leads to the construction of the nitrogen containing ring without starting from any amine moiety. In this context, cyanide-based multicomponent reactions involving the dual nature of the CN moiety has blossomed in an unprecedented way.
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