4.8 Article

Synthesis of 2-Aminophenols and Heterocycles by Ru-Catalyzed C-H Mono- and Dihydroxylation

期刊

ORGANIC LETTERS
卷 15, 期 10, 页码 2334-2337

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AMER CHEMICAL SOC
DOI: 10.1021/ol400437a

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资金

  1. Ministry of Science and Technology [2011CB965300]
  2. National Natural Science Foundation of China [21142008]
  3. Tsinghua University
  4. Tsinghua University Initiative Scientific Research Program

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A novel and efficient synthesis of 2-aminophenols, 2-aminobenzene-1,3-diols, and heterocycles through Ru-catalyzed C-H mono- and dihydroxylation of anilides has been developed with a new directing group strategy. The reaction demonstrates excellent reactivity, regioselectivity, good functional group tolerance, and high yields.

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