期刊
ORGANIC LETTERS
卷 15, 期 4, 页码 721-723出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303549c
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资金
- Grants-in-Aid for Scientific Research [22350016] Funding Source: KAKEN
Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC50 value of 2.2 mu M.
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