期刊
ORGANIC LETTERS
卷 15, 期 18, 页码 4810-4813出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol4022029
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资金
- EPSRC
- MEC [CTQ2010-16226]
- FPU
A one-pot synthesis of chiral amino alcohols from alpha,beta-unsaturated aldehydes is reported which circumvents competitive 1,2-versus 1,4-boryl addition, by means of using a sterically hindered amine-derived imine. In addition to the complete chemoselectivity, modification of the Cu(I) catalyst with readily available chiral diphosphines, such as (R)-DM-BINAP, gave the 1,4-boryl addition products with high levels of asymmetric induction.
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