期刊
ORGANIC LETTERS
卷 15, 期 18, 页码 4710-4713出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol402023c
关键词
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资金
- Alfred P. Sloan foundation
- NSF [CHE-1150393, DBI-0619576]
- NIGMS [RO1GM087581]
Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural RNA or for the analoging of ribonucelosides. Lastly, the procedure was extended to ribavirin a potent antiviral therapeutic.
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