4.8 Article

In(III)/PhCO2H Binary Acid Catalyzed Tandem [2+2] Cycloaddition and Nazarov Reaction between Alkynes and Acetals

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ORGANIC LETTERS
卷 15, 期 17, 页码 4496-4499

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AMER CHEMICAL SOC
DOI: 10.1021/ol4020464

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  1. Ministry of Science and Technology [2012CB821600]
  2. Natural Science Foundation of China [NSFC 21202170, 21025208]
  3. Chinese Academy of Sciences

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A facile tandem [2 + 2] cycloaddition and Nazarov reaction has been developed. The combination of In(OTf)(3) and benzoic acid was found to synergistically promote the coupling of alkynes and acetals to form 2,3-disubstituted indanones in excellent yield and diastereoselectivity.

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