期刊
ORGANIC LETTERS
卷 15, 期 9, 页码 2214-2217出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400769t
关键词
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资金
- Boehringer Ingelheim (Canada), Ltd.
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- University of Saskatchewan
An electron-deficient, valine-derived triazolium salt is shown to catalyze a highly chemo- and enantioselective cross-benzoin reaction between aliphatic aldehydes and alpha-ketoesters. This methodology represents the first high yielding and highly enantioselective intermolecular cross-benzoin reaction using an organocatalyst (up to 94% ee). Further diastereoselective reduction of the products gives access to densely oxygenated compounds with high chemo- and diastereoselectivity.
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