期刊
ORGANIC LETTERS
卷 15, 期 9, 页码 2182-2185出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400729v
关键词
-
资金
- Boehringer Ingelheim (Canada) Ltd.
- NSERC
- Swiss National Science Foundation
Unprotected secondary amines are directly alkylated by C-H functionalization adjacent to nitrogen, thereby opening new routes toward the synthesis of alpha- and beta-alkylated N-heterocycles. alpha-Alkylated piperidine, piperazine, and azepane products are prepared from heterocycles and alkenes in an atom-economic reaction with excellent regio- and diastereoselectivity. beta-Alkylated N-heterocycles are synthesized via a scalable one-pot alkylation/cyclization procedure generating 3-methylated azetidines, pyrrolidines, and piperidines.
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