期刊
ORGANIC LETTERS
卷 15, 期 5, 页码 1100-1103出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol400135n
关键词
-
资金
- National Institutes of Health [CA042056, CA115526]
- Skaggs Institute for Chemical Biology
The regioselective intermolecular coupling reaction of vindoline with a wide range of substrates including beta-ketoesters, beta-diketones, beta-ketoaldehydes, beta-ketonitriles, malononitriles, and beta-cyanoesters provides an opportunity for the synthesis of vinblastine analogues containing deep-seated changes in the upper velbanamine subunit The transition-metal-free hypervalent iodine(III)-promoted intermolecular sp(3)/sp(2) coupling, representing a special class of selective C-H activation with direct carbon carbon bond formation, proceeds with generation of a quaternary center capable of incorporation of the vinblastine C16' methyl ester and functionalized for subsequent divergent heterocycle introduction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据