Isocyanide-Based Multicomponent Reactions: Catalyst-Free Stereoselective Construction of Polycyclic Spiroindolines

A novel catalyst-free one-pot tandem reaction for the stereoselective construction of polycyclic spiroindolines was developed. This method offers a straightforward access to structurally diverse polycyclic spiroindoline derivatives in high yields (up to 90%) with excellent levels of diastereoselectivity.