期刊
ORGANIC LETTERS
卷 15, 期 10, 页码 2550-2553出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401053y
关键词
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资金
- Swiss National Science Foundation
- SCIEX program (Switzerland)
- European PANACREAS FP7 project
- IV Plan Propio de Investigacion of the University of Seville
An efficient method has been developed for the preparation of yet unknown acyclic mixed anhydrides of carboxylic and sulfinic acids. Sterically hindered 2-methylbut-3-ene-2-sulfinyl carboxylates add primary and secondary amines preferentially onto the carbonyl moieties realizing a new method for the one-pot preparation of carboxamides. It uses 1:1 mixtures of carboxylic acids and amines without a base, requires no excess of reagents, and liberates only volatile coproducts. Protected di- and tripeptides have been prepared in solution without epimerization by application of this method.
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