期刊
ORGANIC LETTERS
卷 15, 期 14, 页码 3562-3565出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol401384v
关键词
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资金
- National Institute of General Medical Sciences [PO1GM084077]
- National Science Foundation- Emerging Frontiers in Research and Innovation-MIKS [1136903]
- Department of Energy, Bioenergy Technologies Office
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [1136903] Funding Source: National Science Foundation
Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species.
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