Rhodium(III)-Catalyzed Intermolecular Direct Amidation of Aldehyde C H Bonds with N-Chloroamines at Room Temperature

A Rh(III)-catalyzed direct aldehyde C-H amidation from aldehydes and N-chloroamines, prepared in situ from amines, has been developed via C-H bond activation under very mild reaction conditions. A variety of primary and secondary amines were used to afford the corresponding amides in moderate to excellent yields.