Amphipathic α-Helix Mimetics Based on a 1,2-Diphenylacetylene Scaffold

In order to mimic amphipathic alpha-helices, a novel scaffold based on a 1,2-diphenylacetylene was designed. NMR and computational modeling confirmed that an intramolecular hydrogen bond favors conformations of the 1,2-diphenylacetylene that allow for accurate mimicry of the i, i + 7 and i + 2, i + 5 side chains found on opposing faces of an alpha-helix.