期刊
ORGANIC LETTERS
卷 15, 期 5, 页码 1004-1007出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303459x
关键词
-
资金
- [2105]
- Grants-in-Aid for Scientific Research [21106009, 21106001] Funding Source: KAKEN
The enantioselective total synthesis of (+)-colletoic acid, a potent naturally occurring 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor, is described. This total synthesis features a highly enantioselective catalytic asymmetric intramolecular cyclopropanation of an alpha-diazo-beta-keto diphenylphosphine oxide and five highly stereoselective reactions (cyclopropane opening, Diels-Alder reaction, iodolactonization, alkene formation, and reduction of alpha,beta-unsaturated carboxylic acid).
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