期刊
ORGANIC LETTERS
卷 15, 期 1, 页码 180-183出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303240a
关键词
-
资金
- Marie Curie ITN BIOTRAINS' [238531]
- MICINN
A series of synthetic nicotinamide cofactors were synthesized to replace natural nicotinamide cofactors and promote enoate reductase (ER) catalyzed reactions without compromising the activity or stereoselectivity of the bioreduction process. Conversions and enantioselectivities of >99% were obtained for C=C bioreductions, and the process was successfully upscaled. Furthermore, high chemoselectivity was observed when employing these nicotinamide cofactor mimics (mNADs) with crude extracts in ER-catalyzed reactions.
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