Palladium-Assisted Regioselective C-H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source

A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as CN source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be Efficiently cyanated through C-H bond activation with high regioselectivity.